Planning to Visit the Philippines Soon?

There are hundreds of tourists attractions in the Philippines. But as a lover of the Island of Marinduque (Home of the Morions and Heart of the Philippines), I am indeed partial to its beauty, charm and its friendly and hospitable residents. Therefore, help me achieve my dream of seeing this island becomes a world tourist destination, by telling all your friends and relatives about this site. Welcome, to you all, new readers and faithful followers of this site! The photo above is Poctoy White Beach in Torrijos, Marinduque with beautiful and majestic Mt Malindig in the background. Some of the photos and videos on this site, I do not own. However, I have no intention on infringing your copyrights.

Monday, October 21, 2019

Drugs for the Treatment of Malaria

From slideshare.net
One of the highlights in my employment with FDA was my promotion to GS-14 Expert Status in 1993. I started in 1990 as a Chemistry Reviewer (GS-13).

Press Release of My GS-14 Promotion, 1993
One of the areas of my FDA (GS-14) expertise was Anti-malarial drug products. Therefore, my interest with drugs for the treatment of malaria has never stopped even 17 years after my retirement.  This article summarizes the current FDA approved drugs for the treatment of malaria for your reading pleasure and information.

Antimalarial medications, also known as antimalarials, are designed to prevent or cure malaria. Such drugs may be used for some or all of the following:
  • Treatment of malaria in individuals with suspected or confirmed infection
  • Prevention of infection in individuals visiting a malaria-endemic region who have no immunity (malaria prophylaxis)
  • Routine intermittent treatment of certain groups in endemic regions (intermittent preventive therapy)
Some antimalarial agents, particularly chloroquine and hydroxychloroquine, are also used in the treatment of rheumatoid arthritis and lupus-associated arthritis.

Current practice in treating cases of malaria is based on the concept of combination therapy (e.g., Coartem), since this offers several advantages, including reduced risk of treatment failure, reduced risk of developing resistance, enhanced convenience, and reduced side-effects. Prompt and accurate parasitological confirmation by microscopy, or alternatively by rapid diagnostic tests, is recommended in all patients suspected of malaria before treatment is started.

Here's a short video made by WHO about malaria.

https://youtu.be/gwYIyjwYluc

The following list of medications are in some way related to, or used in the treatment of this condition. The Chemistry, Manufacturing and Control (CMC) of some of these drugs were reviewed and approved by me as the Chemistry Reviewer and Team Leader if the Division of Anti-Infective Drug Products from 1990 to 2002.


Drug name Rx / OTC Preg CSA Reviews Rating
artemether / lumefantrine C N 4
9.0
Coartem C N 4
9.6
Malarone C N 3
7.0
mefloquine B N 6
2.8
doxycycline D N 5
8.0
Plaquenil N N Add
0.0
chloroquine N N 1
10
hydroxychloroquine N N Add
0.0
atovaquone / proguanil C N 3
7.0
clindamycin B N Add
0.0
Doxy 100 D N 1
10
primaquine N N Add
0.0
atovaquone C N 1
10
Lariam B N 5
3.3
Doryx D N Add
0.0
Cleocin B N Add
0.0
Monodox D N Add
0.0
Vibramycin D N Add
0.0
Morgidox D N Add
0.0
Oraxyl D N Add
0.0
Vibra-Tabs D N Add
0.0
Doryx MPC D N Add
0.0
Ocudox D N Add
0.0
Cleocin HCl B N Add
0.0








 




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