https://theintellectualmigrants.blogspot.com/2025/08/cameron-quin-of-henosis-life.html
Where the Heck is Marinduque?
Marinduque:Land of the Morions and Heart of the Philippines, Related website: www.marinduqueawaitsyou.blogspot.com
Planning to Visit the Philippines Soon?
Thursday, August 7, 2025
The Corpse Flower in Bloom at USBG
Wednesday, August 6, 2025
My Play with Words- Part 1 of 5 Series
Why Intelligent Language Still Matters in a Loquacious World
In a world where ubiquitous chatter fills every corner of the internet, from social media to podcasts, it’s easy to assume that the most loquacious voices carry the most value. But more often than not, true depth hides in the recesses of esoteric thought, where words carry centuries of intellectual weight and cultural nuance. This isn’t just semantics—it’s a revival of language that challenges, inspires, and sometimes even confounds.
Consider epistemology, the rigorous study of knowledge and justified belief. At first glance, it may seem recondite, reserved for dusty philosophy books and late-night academic debates. Yet, it lies at the heart of every truth-seeking journey—from scientific discovery to personal conviction. Such foundational ideas are not axiomatic in a world awash with misinformation and fast takes.
Our ability to navigate this complex landscape relies on being sagacious, exercising discernment in separating signal from noise. We must resist obfuscation, the tactic used by those who intentionally cloud meaning, whether in politics, marketing, or even interpersonal relationships. In contrast, clarity—however ineffable at times—becomes a beacon of understanding.
Language also allows us to explore contrast, and what better tool for this than juxtaposition? We live in a time where ideas are often antithetical, polar opposites locked in fierce ideological battles. Maintaining equanimity amid such tension requires not only composure but also an understanding of verisimilitude—the art of distinguishing what merely seems true from what is.
Yet, not all noise is semantic. The world often feels like a cacophony of voices, each more desperate than the last to be heard. In this atmosphere, sycophants thrive, flattering those in power to climb ladders not built by merit but by manipulation. Their obsequious nature may win them favor, but rarely respect.
There is, however, beauty in this complexity. Though rarely uttered in conversation, pulchritude reminds us that elegance—in language or life—need not shout to be seen. At times, being magnanimous, especially to rivals or detractors, speaks volumes louder than the harshest critique.
Of course, this isn’t always easy. Some individuals remain recalcitrant, refusing to yield to logic or empathy. Others may appear irascible, triggered by mere disagreement, revealing just how fragile certainty can be. Such behavior often stems from solipsistic tendencies, where the world is viewed only through the lens of the self.
The quintessential thinker, however, recognizes change as inevitable. Life’s many vicissitudes remind us that stability is often a mirage. The pernicious effects of ignorance, propaganda, or blind obedience can erode democratic ideals if left unchecked.
To combat this, we must become perspicacious—capable of seeing beyond the surface to uncover hidden truths. Not everything worth knowing is easy to grasp. Some ideas are obscure, others paradoxically ineffable, but that’s what makes them worth pursuing.
In embracing these intelligent-sounding words, we’re not merely flexing vocabulary muscles. We’re preserving a richer form of communication—one that values precision, beauty, and depth. As the digital world grows louder and more distracted, perhaps a return to this kind of language isn’t just admirable. Maybe it’s necessary.
Tuesday, August 5, 2025
My FDA Role After the 9/11 Bombing of the World Trade Center
Ripples of Compassion: My FDA Role After 9/11
📝 Quote: “In the midst of chaos, there is also opportunity.” – Sun Tzu
One of the most impactful moments of my professional life at the FDA came in the wake of an unimaginable tragedy—the September 11 attacks on the World Trade Center. I was honored to be part of the federal response team, specifically reviewing and updating chemistry and manufacturing protocols for treating burn victims. It was a unique and sobering responsibility that tested not only our scientific knowledge but our human capacity for compassion.
I witnessed firsthand the extraordinary courage of first responders, the resilience of survivors, and the seamless collaboration between federal agencies determined to do what was needed, fast and effectively. These were days filled with urgency, purpose, and a deep sense of national solidarity.
That time left a permanent mark on me. It taught me that, even amid catastrophe, small acts of expertise and empathy can ripple outward far beyond what we can see. Whether it was a revised burn treatment protocol or a simple gesture of support to a colleague working overtime, every contribution mattered.
In those moments, I understood more than ever the quiet power of service. And in remembering 9/11, I remember not only the pain but also the deep well of humanity it revealed.
🔍 Summary:
After the 9/11 attacks, I served on the FDA’s emergency response team, reviewing chemistry and manufacturing protocols for two drugs, Sulfamylon and Sulfadene for burn victims. This work deepened my appreciation for public service and showed me that in the darkest times, even the smallest contributions can carry great meaning.
Meanwhile, here's my summary and Reflection on the article: the Collapse of the FDA: and Kennedy Dismantling of the Agency.
As someone who dedicated twelve years of my professional life to the U.S. Food and Drug Administration (FDA)—culminating in my role as a Chemistry Team Leader at the Center for New Drugs and participation on the Emergency Team after 9/11—the recent New York Times Magazine article “On the Collapse of the FDA” by Jeneen Interlandi (July 20, 2025) hit home on a deeply personal level.
The article details a transformation that many of us who served within the agency could scarcely imagine: the systematic dismantling of an institution designed to protect public health and consumer safety, now threatened under the direction of Health Secretary Robert F. Kennedy Jr.
I will post a SEPARATE article on this topic in my next blogs.
For Details on my involvement after the 9/11 Bombing of the World Trade Center and my FDA years read:
💚https://chateaudumer.blogspot.com/2019/09/the-18th-anniversary-of-bombing-of-wtc.html
https://chateaudumer.blogspot.com/2021/07/our-maryland-and-fda-years-1990-2002.html
Lastly, here's my photo of the Day:
My Batman- One of my Companions here at THD- Keeps me active and not lonely
Monday, August 4, 2025
The Five Stages of Chronic Kidney Disease and Dialysis
This posting is inspired from my recent visit to my nephrologist and my current CKD Diagnoses.
Chronic kidney disease (CKD) is classified into five stages, based on how well your kidneys are filtering waste from your blood. This is typically measured by a calculation called the estimated glomerular filtration rate (eGFR):
Stage 1: Kidney function is normal (eGFR 90 or greater).
Stage 2: Mild loss of kidney function (eGFR 60–89).
Stage 3: Moderate loss of kidney function, further divided into:
3a: eGFR 45–59
3b: eGFR 30–44
Stage 4: Severe loss of kidney function (eGFR 15–29, or roughly 15–29% kidney function).
Stage 5: Kidney failure or end-stage renal disease (eGFR less than 15, or less than 15% kidney function).
If a person is in Stage 4 kidney disease, this means their kidney function is between 15% and 29%, so "only 20% of his kidney is functioning" is a correct way to describe someone at Stage 4. This stage often requires close monitoring by a kidney specialist, and preparations may begin for dialysis or transplant if kidney function continues to decline.
In stage 4 chronic kidney disease (CKD), symptoms are more pronounced and can significantly affect daily life, compared to earlier stages where a person may have few or no symptoms. Here’s how symptoms in stage 4 typically differ from the earlier stages:
Common symptoms appearing or worsening in stage 4 CKD:
Fatigue and weakness: Due to anemia and buildup of waste products, people often feel very tired and weak, more so than in earlier stages.
Swelling (edema): Noticeable swelling in legs, ankles, feet, and sometimes hands and face, due to fluid retention; swelling is usually mild or absent in earlier stages.
Shortness of breath: Fluid buildup in lungs or anemia can cause difficulty breathing.
Nausea and vomiting: As toxins accumulate, nausea and occasional vomiting become more common in stage 4.
Loss of appetite: Eating less and weight loss are more prominent.
Changes in urination: Either more frequent urination at night, foamy urine, or much less urine (sometimes unable to urinate).
Difficulty concentrating/confusion: The buildup of waste affects mental sharpness and can lead to confusion.
Muscle cramps and restless legs: More frequent and severe.
Itching: Increased due to high levels of phosphorus and other waste in the blood.
High blood pressure: Worsens or may become difficult to control.
Comparison with earlier stages:
Early CKD (stages 1-2) is often asymptomatic, sometimes only identified with blood or urine tests.
By stage 3, mild symptoms such as fatigue, mild swelling, or urination changes may be present, but often are not severe.
Symptoms increase in severity and number by stage 4, with a higher risk of complications affecting multiple body systems.
Summary: Stage 4 CKD is marked by more severe symptoms and complications (especially fatigue, swelling, appetite loss, and mental changes) than the earlier stages, meaning patients typically feel much sicker and daily life is often affected.
What is the expected survival rate of persons with Stage 4, that is what is the average time, this person will lead a fairly normal life?
The expected survival and ability to lead a fairly normal life with stage 4 chronic kidney disease (CKD) is highly variable and depends on factors like age, overall health, how well other conditions are managed (such as diabetes or high blood pressure), and how closely treatment recommendations are followed.
On average, studies suggest that older adults (e.g., age 70) newly diagnosed with stage 4 CKD have a life expectancy of about four years. However, this is just an estimate, and many people can live longer—sometimes several years—if they follow their medical plan and maintain a healthy lifestyle.
For older patients with high comorbidity or poor health, the median survival has been reported between 1–4 years, with 1-year survival rates ranging from 29% to more than 80% depending on age, severity, and whether dialysis is started.
Many people with stage 4 CKD can lead a fairly normal life, especially during the initial part of this stage, if they manage symptoms, control blood pressure, eat a kidney-friendly diet, and remain physically active. However, as kidney function continues to decline, symptoms usually worsen, and normal activities may become progressively more difficult.
Summary: Life expectancy in stage 4 CKD can range from 1 to several years, with some patients living as long as four years or more. The period during which a person leads a "fairly normal" life depends greatly on their overall health, adherence to treatment, and other health conditions. Adhering strictly to medical advice can slow progression and maintain quality of life for as long as possible.
What is the quality of life of a person under Dialysis?
The quality of life (QoL) for patients on dialysis is generally lower compared to healthy individuals and is affected by multiple physical, psychological, and social factors:
Patients on hemodialysis often experience chronic fatigue, poor sleep quality, pain, nausea, vomiting, and limitations in physical activity which impact their daily life. They may also suffer from emotional challenges such as anxiety, depression, and feelings of helplessness. The strict dialysis schedule and dependency on equipment and dialysis centers can limit their ability to travel, work, or engage in social activities.
Patients on peritoneal dialysis tend to report somewhat better QoL in some areas, such as more flexibility, less dietary restriction, less dependence on healthcare personnel, and a greater sense of life meaning and social engagement, although they may face other challenges like depression.
The mental health and emotional well-being of dialysis patients can be significantly affected due to the chronic nature of kidney failure and dialysis treatment. Many experience worry, helplessness, and a negative outlook on the future, which further reduces their QoL.
Caregivers of dialysis patients also experience a reduced quality of life, especially physically and mentally, reflecting the burden of caring for someone on dialysis.
Despite these challenges, many patients do feel better after starting dialysis as it reduces toxin buildup and treats anemia, which can improve energy levels and well-being compared to pre-dialysis kidney failure. However, the overall impact of dialysis on daily life remains substantial.
In summary, dialysis patients generally face a reduced quality of life with multiple physical and psychological burdens. However, quality of life can vary depending on the type of dialysis, support systems, and individual coping mechanisms. Personalized care, psychological support, and flexible treatment options can help improve outcomes for dialysis patients.
What is hemodialysis versus peritoneal dialysis
Hemodialysis and peritoneal dialysis are two types of dialysis treatments used to filter and remove waste, excess fluid, and toxins from the blood when the kidneys are no longer functioning adequately.
Hemodialysis:
Blood is removed from the body and filtered through a machine called a dialyzer (artificial kidney).The machine cleans the blood and then returns it to the body.Usually performed in a dialysis center or hospital, but can sometimes be done at home. Typically requires about three to four-hour sessions, three times a week.Needles are placed in a vein at each treatment to access the blood.Causes intermittent filtration and fluid removal.Suitable for patients who want healthcare professionals to manage the treatment.
Peritoneal Dialysis:
Uses the body's own peritoneum (lining of the abdominal cavity) as a natural filter.A dialysis solution (dialysate) is infused into the abdomen through a surgically placed catheter. Waste products and excess fluids pass from blood vessels in the peritoneum into the dialysis fluid. The fluid is later drained and replaced; this exchange can be done multiple times daily or overnight using a machine.Can be done at home, work, or any clean space, providing more independence and flexibility. Less dietary restrictions, continuous filtering means less buildup of waste and fluid. Patients do not require needles as with hemodialysis but require training to perform the exchanges.
Summary of Differences:
Feature | Hemodialysis | Peritoneal Dialysis |
---|---|---|
Filtering mechanism | Machine-based extracorporeal blood filtration | Uses body's peritoneum as a natural filter |
Frequency & duration | About 3-4 hours, 3 times/week | Continuous or daily exchanges, time varies |
Location | Usually in-center, sometimes at home | Usually at home or anywhere clean and private |
Invasiveness | Requires needle access to veins | Requires catheter surgically placed in abdomen |
Lifestyle impact | More disruption; fixed schedule | More flexible; performed by the patient |
Dietary restrictions | More restrictive | Less restrictive |
Suitable for | Patients needing healthcare supervision | Patients able to manage self-care, no abdominal issues |
Choosing between them depends on individual health conditions, lifestyle, personal preference, and kidney function.
Meanwhile, here's my Photo of the Day